| Position£ºzensun.com
- Business Cooperation - Technological Sevrvice |
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1.Animal Study |
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Pharmacodynamics research and screening platform for anti-tumor drugs.
The Company uses various models to screen for cellular toxicity of anti-tumor drugs and tumor therapeutic vaccines, including models of transplanted tumors in nude mice (xenografts) and transgenic mice, and models of spontaneous tumor development in transgenic mice. Moreover, in vitro screening experiments can be implemented here, including cell growth inhibition experiments ([ 3H]-thymidine incorporation, MTT method), CTL or NK (fluorescent labeling method, MTT method) analysis, and cytokine evaluations (ELISPOT), etc. |
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Pharmacodynamics research and screening platform for cardiovascular drugs
The Company is able to provide animal models of cardiac insufficiency and myocarditis, for in vivo drug screening, including hemodynamics experiments on dogs and monkeys, sub-acute or chronic ischemic heart failure models in rats, drug-induced myocarditis models and viral myocarditis models in mice, and congestive heart failure models in dogs. The high rate of success in developing these models on a routine basis allows rapid and comprehensive cardiovascular drug screening. Cell screening can also be implemented, including in vitro culture of myocardial cells, to evaluate drug effects on structure and contractility.
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| 2.Pilot Production |
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Fermentation: optimizing the conditions of fermentation, establishing the best fermentation techniques. |
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Purification: purifying proteins and nucleic acids and establishing the best techniques to satisfy the GLP. |
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Formulation: technical screening for formulation and lyophilization of products. |
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QC testing: establishment of individual drug-based specifications and performance of QC testing of biological products. |
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| 3.Molecular Biology |
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Gene construction: provides service for target gene cloning, gene mutation. |
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Construction of genetically engineered antibodies: cloning of the antibody gene with full sets of VH and VL-based primers; construction of chimeric and humanized antibody genes; construction of small molecule antibody genes. |
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Construction of gene expression system: including Escherichia coli, yeast and CHO expression systems. |
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| 4.Cell Biology |
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Construction of monoclonal antibodies: includes the entire process from preparation of antigen (Ecoli. or CHO cells), animal immunization, cell fusion, positive clone screening, ascites production, to antibody purification and characterization. |
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Production of a polyclonal antibody: by using an efficient antigen-adjuvant cross-linking system, polyclonal antibodies with a high titer such as mouse and rat antibodies, dog antibodies and monkey antibodies can be raised. |
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Establishment of CHO/DHFR- based stable cell lines and large scale cell culture. |
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Research and development of various ELISA testing kits. |
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Cell culture of primary and cell lines: cell growth or inhibition assays, etc. |
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